Encouraging Research Beyond One's Fields

MNU encourages our faculty to do research around the world.

For example, we do studies on articles such as these (below):

Review

Pharmacol Rep
2020 Aug;72(4):769-782.

doi: 10.1007/s43440-020-00112-3.

Epub 2020 May 27.

Effects of curcumin on neurological diseases: focus on astrocytes

Samira Eghbaliferiz Faegheh Farhadi George E BarretoMuhammed Majeed  Amirhossein Sahebkar 

  Affiliations

Abstract

Astrocytes are the most abundant glial cells in the central nervous system, and are important players in both brain injury and neurodegenerative disease. Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), the major active component of turmeric, belongs to the curcuminoid family that was originally isolated from the plant Curcuma longa. Several studies suggest that curcumin may have a beneficial impact on the brain pathology and aging. These effects are due to curcumin's antioxidant, free-radical scavenging, and anti-inflammatory activity. In light of this, our current review aims to discuss the role of astrocytes as essential players in neurodegenerative diseases and suggest that curcumin is capable of direct inhibition of astrocyte activity with a particular focus on its effects in Alexander disease, Alzheimer's disease, ischemia stroke, spinal cord injury, Multiple sclerosis, and Parkinson's disease.

Keywords: Brain; Curcuminoids; Neurodegenerative disease.

Go to:

Effects of curcumin on neurological diseases: focus on astrocytes

Credit:

https://pubmed.ncbi.nlm.nih.go...

Нийтэлсэн огноо: 1 долоо хоног, 2 өдөр өмнө